Search Results - Monoclonal+Antibodies

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Mouse monoclonal antibody against recombinant human Rab escort protein-1 (2F1)

Rab geranylgeranyl transferase (GG transferase) is a two-component enzyme that attaches 20-carbon isoprenoid groups to cysteine residues in Rab proteins, a family of guanosine triphosphate-binding proteins that regulate vesicular traffic. The mutant gene in human choroideremia, an X-linked form of retinal degeneration, encodes a protein that resembles...

Published: 5/5/2011 | Updated: 5/5/2011 | Inventor(s): Michael Brown, Joseph Goldstein, M C Seabra

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Category(s): Monoclonal Antibodies

Mouse monoclonal antibody to very low density lipoprotein receptor VLDL-R (6A6)

Low Density Lipoprotein Receptor-related Protein Mediates Endocytosis of Monoclonal Antibodies in Cultured Cells and Rabbit Liver http://www.jbc.org/content/265/34/21355.full.pdf+html Monoclonal antibodies that bound to the external domain of the rabbit low density lipoprotein receptorrelated protein (LRP) were taken into rabbit fibroblasts by...

Published: 5/5/2011 | Updated: 5/5/2011 | Inventor(s): Michael Brown, Joseph Goldstein

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Category(s): Monoclonal Antibodies

Monoclonal antibody anti-SCAP (9D5)

SREBP cleavage-activating protein (SCAP) stimulates the proteolytic cleavage of membrane-bound SREBPs, thereby initiating the release of NH2-terminal fragments from cell membranes. The liberated fragments enter the nucleus and stimulate transcription of genes involved in synthesis and uptake of cholesterol and fatty acids. Sterols repress cleavage...

Published: 5/5/2011 | Updated: 5/5/2011 | Inventor(s): Michael Brown, Joseph Goldstein

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Category(s): Monoclonal Antibodies

Mouse monoclonal antibody for LDLR (C7)

A solid phase ligand binding assay for the low density lipoprotein (LDL) receptor that takes advantage of the domain structure of the protein. An antibody directed against one domain, e.g. the cytoplasmic tail, is adsorbed to a microtiter well. A detergent solution containing the LDL receptor is added, and the receptor is allowed to bind to the...

Published: 5/5/2011 | Updated: 5/5/2011 | Inventor(s): Michael Brown, Joseph Goldstein

Keywords(s):

Category(s): Monoclonal Antibodies